反应详情

To a solution of 2-tert-butyl-5-nitrobenzene-1-sulfonyl chloride (100 mg, 0.36 mmol) in ether (2 mL) was added aqueous NH4OH (128 μL, 3.6 mmol) at 0° C. The mixture was stirred at room temperature overnight, diluted with water and extracted with ether. The combined ether extracts were washed with brine and dried over Na2SO4. After removal of solvent, the residue was purified by column chromatography (0-50% EtOAc-Hexane) to give 2-tert-butyl-5-nitrobenzene-1-sulfonamide (31.6 mg, 34%).

1. extractionextracted with ether
2. washThe combined ether extracts were washed with brine
3. dry with materialdried over Na2SO4
4. customAfter removal of solvent
5. customthe residue was purified by column chromatography (0-50% EtOAc-Hexane)