Lithium hydroxide, monohydrate → HCID 10178371, compound

Participants

Reaction Steps

455 mg (10.8 mmol) of LiOH.H2O were dissolved in 90 ml of THF:H2O 1:1; 873 mg (2.17 mmol) of methyl E-4(3-(1-adamantyl)-4-methoxyphenyl)cinnamate were added and the solution thus obtained was kept under stirring at room temperature for 2 days. The THF was evaporated, acidified with 2N HCl and the white precipitate was filtered. The solid was washed with AcOEt and Et2O, to obtain 792 mg (94%) of the title compound.

Provenance & Evidence