Lithium hydroxide, monohydrate → HCID 10178371, compound

HRID 423944Notes

Reaction equation

HRID 423944 reaction equation
O[Li].O.[C:4]12([C:14]3[CH:15]=[C:16]([C:22]4[CH:33]=[CH:32][C:25](/[CH:26]=[CH:27]/[C:28]([O:30]C)=[O:29])=[CH:24][CH:23]=4)[CH:17]=[CH:18][C:19]=3[O:20][CH3:21])[CH2:13][CH:8]3[CH2:9][CH:10]([CH2:12][CH:6]([CH2:7]3)[CH2:5]1)[CH2:11]2>C1COCC1.O>[C:4]12([C:14]3[CH:15]=[C:16]([C:22]4[CH:23]=[CH:24][C:25](/[CH:26]=[CH:27]/[C:28]([OH:30])=[O:29])=[CH:32][CH:33]=4)[CH:17]=[CH:18][C:19]=3[O:20][CH3:21])[CH2:13][CH:8]3[CH2:9][CH:10]([CH2:12][CH:6]([CH2:7]3)[CH2:5]1)[CH2:11]2

Participants

4

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 10111737HCID 10111737, compound

Product 1

HCID 10178371HCID 10178371, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 21881883Oxolane--water (1/1)Solvent

Procedure

455 mg (10.8 mmol) of LiOH.H2O were dissolved in 90 ml of THF:H2O 1:1; 873 mg (2.17 mmol) of methyl E-4(3-(1-adamantyl)-4-methoxyphenyl)cinnamate were added and the solution thus obtained was kept under stirring at room temperature for 2 days. The THF was evaporated, acidified with 2N HCl and the white precipitate was filtered. The solid was washed with AcOEt and Et2O, to obtain 792 mg (94%) of the title compound.

Workup

  1. customthe solution thus obtained
  2. customThe THF was evaporated
  3. filtrationthe white precipitate was filtered
  4. washThe solid was washed with AcOEt and Et2O

Sources & evidence

ORD record
ord-77f2cd9ff4d74870bef0f21359547915
Source dataset
uspto-grants-2012_01
Patent number
US08101793B2

Reaction notes

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