Ammonium formate → 6-Benzyl-1,4-diazepan-6-ylamine

Participants

Role	Name	HCID	Charge
Reactant	Ammonium formate	HCID 2723923	—
Reactant	1,4-Dibenzyl-6-benzyl-6-nitro-1,4-diazepane	HCID 58599847	—
Catalyst	Palladium	HCID 23938	—
Solvent	Methanol	HCID 887	—
Product	6-Benzyl-1,4-diazepan-6-ylamine	HCID 59381308	—

Reaction Conditions

Temperature	60 °C

Reaction Steps

Pd—C 10% was added to a solution of 5 (200 mg, 0.27 mmol) and ammonium formate (0.75 g, 12.0 mmol) in methanol (10.0 mL) and the mixture was stirred at 60° C. for 1 h. The catalyst was removed and the methanolic solution was concentrated to give the amine 6 as an oil, which was dried under vacuum to give a foamy solid. Yield: 95 mg (92%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08105567B2
Source dataset	uspto-grants-2012_01
ORD ID	ord-1224163f7a3c489393c3be46f696d5a4
Source note	uspto-grants-2012_01