2-Bromo-5-methylbenzoic acid → 2-Bromo-5-methyl-1-(methoxymethoxymethyl)benzene

HRID 424363Notes

Reaction equation

HRID 424363 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:3]=1[C:4](O)=[O:5].BrC1C=CC(Cl)=CC=1[CH2:20][O:21][CH2:22]OC>>[Br:1][C:2]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:3]=1[CH2:4][O:5][CH2:20][O:21][CH3:22]

Participants

3

Reactant 2

HCID 2280802-Bromo-5-methylbenzoic acidHCID 590246772-Bromo-5-chloro-1-(methoxymethoxymethyl)benzene

Product 1

HCID 590087822-Bromo-5-methyl-1-(methoxymethoxymethyl)benzene

Procedure

This compound was made from 2-bromo-5-methylbenzoic acid in the same manner as compound 18d: 1H NMR (300 MHz, DMSO-d6) δ (ppm) 2.27 (s, 3H), 3.30 (s, 3H), 4.51 (s, 2H), 4.68 (s, 2H), 7.05 (dd, J=7.9, 2.3 Hz, 1H), 7.30 (d, J=1.5 Hz, 1H), 7.46 (d, J=8.2 Hz, 1H).

Sources & evidence

ORD record
ord-684cad13069e4bb3983689576aff084b
Source dataset
uspto-grants-2012_01
Patent number
US08106031B2

Reaction notes

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