2-Bromo-6-fluorobenzoic acid → 2-Bromo-6-fluoro-1-(methoxymethoxymethyl)benzene

HRID 424366Notes

Reaction equation

HRID 424366 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4](O)=[O:5].BrC1C=CC(Cl)=CC=1[CH2:20][O:21][CH2:22]OC>>[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[CH2:4][O:5][CH2:20][O:21][CH3:22]

Participants

3

Reactant 2

HCID 3026212-Bromo-6-fluorobenzoic acidHCID 590246772-Bromo-5-chloro-1-(methoxymethoxymethyl)benzene

Product 1

HCID 667049862-Bromo-6-fluoro-1-(methoxymethoxymethyl)benzene

Procedure

This compound was made from 2-bromo-6-fluorobenzoic acid in the same manner as compound 18d: 1H NMR (300 MHz, CDCl3) δ (ppm) 3.43 (s, 3H), 4.74 (s, 2H), 4.76 (d, J=2.1 Hz, 2H), 7.05 (t, J=9.1 Hz, 1H), 7.18 (td, J=8.2, 5.9 Hz, 1H), 7.40 (d, J=8.2 Hz, 1H).

Sources & evidence

ORD record
ord-4ee919163a0f4208ae4c84976794e4bf
Source dataset
uspto-grants-2012_01
Patent number
US08106031B2

Reaction notes

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