HCID 11265111, compound → HCID 11846121, compound

HRID 424378Notes

Reaction equation

HRID 424378 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[CH2:9][CH2:10][O:11]COC.Cl[C:16]1[CH:17]=[C:18]([B:22]2C3C=CC(F)=CC=3CO2)[CH:19]=[CH:20][CH:21]=1>>[F:8][C:5]1[CH:6]=[CH:7][C:2]2[B:22]([C:18]3[CH:19]=[CH:20][CH:21]=[CH:16][CH:17]=3)[O:11][CH2:10][CH2:9][C:3]=2[CH:4]=1

Participants

3

Reactant 2

HCID 11265111HCID 11265111, compoundHCID 11845755HCID 11845755, compound

Product 1

HCID 11846121HCID 11846121, compound

Procedure

This compound was synthesized from 22a and 7a in a similar manner to compound 9f: colorless oil; 1H NMR (300 MHz, CDCl3) δ (ppm) 3.02 (t, J=6.1 Hz, 2H), 4.34 (t, J=6.1 Hz, 2H), 6.9-7.1 (m, 2H), 7.4-7.6 (m, 3H), 7.8-7.9 (m, 3H); ESI-MS m/z 227 (M+H)+; HPLC purity 95.3%; Anal (C14H12BFO 0.1H2O)C, H.

Sources & evidence

ORD record
ord-8f20df0452a84cf1bd41fe050bfd0352
Source dataset
uspto-grants-2012_01
Patent number
US08106031B2

Reaction notes

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