反应详情

温度

110 °C

6.0 g (4-chloro-phthalazin-1-yl)-hydrazine (compound C1) are suspended in a mixture of 160 ml toluene and 18 ml triethylamine at 60° C. and treated with a solution of 6.0 g 4-methoxy-benzoyl chloride in 48 ml toluene. The mixture is stirred at 110° C. for 6 h, cooled to ambient temperature, filtered with suction and rinsed with toluene. The solid is recrystallized from N,N-dimethylformamide, the precipitate is washed with water and dried to yield 5.2 g of the title compound (m.p.: 192-193° C.).

1. temperaturecooled to ambient temperature
2. filtrationfiltered with suction
3. washrinsed with toluene
4. customThe solid is recrystallized from N,N-dimethylformamide
5. washthe precipitate is washed with water
6. customdried