Hydrazine hydrate (1:1) → 1-Chloro-4-hydrazinophthalazine

HRID 424409Notes

Reaction equation

HRID 424409 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5](Cl)=[N:4][N:3]=1.O.[NH2:14][NH2:15]>C(O)C>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([NH:14][NH2:15])=[N:4][N:3]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 784901,4-Dichlorophthalazine

Product 1

HCID 27937521-Chloro-4-hydrazinophthalazine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

10 g commercially available dichlorophthalazine are added portionwise at 90° C. to a solution of 50 ml ethanol and 20 ml hydrazine hydrate. After 10 min the reaction mixture is cooled to ambient temperature, the precipitate is filtered with suction and rinsed with ethanol to yield 8.4 g of the title compound.

Workup

  1. filtrationthe precipitate is filtered with suction
  2. washrinsed with ethanol

Sources & evidence

ORD record
ord-893d30f7cb2342949dd6297b5f3e6bde
Source dataset
uspto-grants-2012_01
Patent number
US08106047B2

Reaction notes

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