Hydrochloric Acid → HCID 66703935, compound

Participants

Reaction Steps

Hydrogen chloride in ethyl acetate solution (4N) was added to a solution of tert-butyl (2S)-2-(4-(3-(pyrrolidin-1-yl)propyloxy)phenyl)morpholine-4-carboxylate (1.13 g, 2.89 mmol) in methanol. The mixture was stirred for one hour at room temperature and the solvent was evaporated under reduced pressure to give a white solid, which was recrystallized from ethanol to afford (2S)-2-(4-(3-(pyrrolidin-1-yl)propyloxy)phenyl)morpholine hydrochloride (0.9 g, 86%) as white crystals.

Provenance & Evidence