Hydrochloric Acid → HCID 66703935, compound

HRID 424439Notes

Reaction equation

HRID 424439 reaction equation
[ClH:1].[N:2]1([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:16]=[CH:15][C:14]([C@@H:17]3[O:22][CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18]3)=[CH:13][CH:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3]1>C(OCC)(=O)C.CO>[ClH:1].[N:2]1([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:12]=[CH:13][C:14]([C@@H:17]3[O:22][CH2:21][CH2:20][NH:19][CH2:18]3)=[CH:15][CH:16]=2)[CH2:6][CH2:5][CH2:4][CH2:3]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 66704009HCID 66704009, compound

Product 1

HCID 66703935HCID 66703935, compoundYield 86%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

Hydrogen chloride in ethyl acetate solution (4N) was added to a solution of tert-butyl (2S)-2-(4-(3-(pyrrolidin-1-yl)propyloxy)phenyl)morpholine-4-carboxylate (1.13 g, 2.89 mmol) in methanol. The mixture was stirred for one hour at room temperature and the solvent was evaporated under reduced pressure to give a white solid, which was recrystallized from ethanol to afford (2S)-2-(4-(3-(pyrrolidin-1-yl)propyloxy)phenyl)morpholine hydrochloride (0.9 g, 86%) as white crystals.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customto give a white solid, which
  3. customwas recrystallized from ethanol

Sources & evidence

ORD record
ord-ebea68de88de442583e0338977c797cd
Source dataset
uspto-grants-2012_01
Patent number
US08106045B2

Reaction notes

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