反应详情

1,1′-Carbonyldiimidazole (540 mg, 3.30 mmol) was added to a solution of 4-[(2S)-4-((1R)-1-phenyl-ethy)-morpholin-2-yl]-benzoic acid (944 mg, 3.03 mmol) in dichloromethane at 0° C. After stirring for 2 hours, ethanolamine (0.36 ml, 6.0 mmol) was added to the reaction mixture and the mixture was stirred over night. The resulting suspension was concentrated in vacuo and the residue was purified by silica gel chromatography (ethyl acetate-hexane) to afford N-(2-hydroxy-ethyl)-4-[(2S)-4-((1R)-1-phenyl-ethy)-morpholin-2-yl]-benzamide (789 mg, 73%.) as a colorless oil.

1. stirringthe mixture was stirred over night
2. concentrationThe resulting suspension was concentrated in vacuo
3. customthe residue was purified by silica gel chromatography (ethyl acetate-hexane)