反应详情

To a solution of N-(4-(2-(dimethylamino)ethyl)-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)thiophene-2-carboximidamide (57 mg, 0.164 mmol) in methanol (2 mL) was added hydrogen chloride (1 M in diethyl ether; 0.493 mL, 0.493 mmol). The resulting mixture was then concentrated in vacuo to give a yellow-orange solid (68 mg, 99%). 1H NMR (DMSO-d6) δ 11.49 (s, 1H), 11.09 (brs, 1H), 9.74 (s, 1H), 8.78 (s, 1H), 8.19-8.12 (m, 2H), 7.39-7.33 (m, 1H), 7.15-7.05 (m, 2H), 6.66-6.60 (m, 1H), 3.79-3.70 (m, 2H), 3.70-3.60 (m, 2H), 3.32-3.21 (m, 2H), 3.16-3.08 (m, 2H), 2.81-2.74 (m, 6H); HRMS (C17H23N4S2, MH+, free base): calculated: 347.1358, observed: 347.1349. HPLC purity: 95% by area.

1. concentrationThe resulting mixture was then concentrated in vacuo