反应详情

10% palladium on charcoal (350 mg) was added to a soln. of N-(3-benzyloxypropoxymethyl)-2,4,6-trichloro-N-methylbenzenesulfonamide (2.60 g, 5.7 mmol) in THF (100 ml) under argon and hydrogenation was carried out at RT under 3 bar. The reaction soln. was then filtered through Celite, the residue on the filter was washed with THF (50 ml) and the filtrate was concentrated i. vac. The crude product (1.63 g) was purified by means of flash chromatography with cyclohexane/EtOAc (1:1).

1. customwas carried out at RT under 3 bar
2. filtrationwas then filtered through Celite
3. washthe residue on the filter was washed with THF (50 ml)
4. concentrationthe filtrate was concentrated i
5. customThe crude product (1.63 g) was purified by means of flash chromatography with cyclohexane/EtOAc (1:1)