1-(Chloromethyl)-2-fluoro-4-methoxybenzene → 6-Amino-2-[(2-fluoro-4-methoxybenzyl)thio]pyrimidin-4(3H)-one

HRID 424668Notes

Reaction equation

HRID 424668 reaction equation
O.[NH2:2][C:3]1[CH:8]=[C:7]([OH:9])[N:6]=[C:5]([SH:10])[N:4]=1.[F:11][C:12]1[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=[CH:16][C:13]=1[CH2:14]Cl>>[NH2:2][C:3]1[N:4]=[C:5]([S:10][CH2:14][C:13]2[CH:16]=[CH:17][C:18]([O:20][CH3:21])=[CH:19][C:12]=2[F:11])[NH:6][C:7](=[O:9])[CH:8]=1

Participants

3

Reactant 2

HCID 219907211-(Chloromethyl)-2-fluoro-4-methoxybenzeneHCID 178507962HCID 178507962, compound

Product 1

HCID 1363915406-Amino-2-[(2-fluoro-4-methoxybenzyl)thio]pyrimidin-4(3H)-one

Procedure

The subtitle compound was prepared according to the procedure of Example 1 step i) treating 4-amino-6-hydroxy-2-mercaptopyrimidine monohydrate (1.86 g) with 2-fluoro-4-methoxybenzyl chloride (2.00 g) to afford the subtitle compound as a white solid. Yield: 2.64 g.

Workup

  1. customThe subtitle compound was prepared

Sources & evidence

ORD record
ord-167ff63a5b684b788cdf5e6c4ada53b6
Source dataset
uspto-grants-2012_01
Patent number
US08106063B2

Reaction notes

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