HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Chloromethyl)-2-fluoro-4-methoxybenzene → 6-Amino-2-[(2-fluoro-4-methoxybenzyl)thio]pyrimidin-4(3H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Chloromethyl)-2-fluoro-4-methoxybenzene | HCID 21990721 | — |
| Reactant | HCID 178507962 | HCID 178507962 | — |
| Product | 6-Amino-2-[(2-fluoro-4-methoxybenzyl)thio]pyrimidin-4(3H)-one | HCID 136391540 | — |
Reaction Steps
The subtitle compound was prepared according to the procedure of Example 1 step i) treating 4-amino-6-hydroxy-2-mercaptopyrimidine monohydrate (1.86 g) with 2-fluoro-4-methoxybenzyl chloride (2.00 g) to afford the subtitle compound as a white solid. Yield: 2.64 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08106063B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-167ff63a5b684b788cdf5e6c4ada53b6 |
| Source note | uspto-grants-2012_01 |