反应详情

温度

120 °C

A solution of 2-(tosyloxymethyl)oxetane (27 g, 111.4 mmol) (prepared according to A. O. Fitton et al., Synthesis 1987, (12), 1140-2) and potassium phtalimide (20.64 g, 111.4 mmol) in DMF (200 ml) is stirred at a temperature of 120° C. for 18 hours, then evaporated in vacuo. The residue is taken up in ethyl acetate, the organic layer washed with water and brine, dried (Na2SO4), filtered, and evaporated to dryness. The crude solid product (19.8 g, 82%) is used in the next step without further purification.

1. customevaporated in vacuo
2. washthe organic layer washed with water and brine
3. dry with materialdried (Na2SO4)
4. filtrationfiltered
5. customevaporated to dryness
6. customThe crude solid product (19.8 g, 82%) is used in the next step without further purification