反应详情

温度

50 °C

To an ambient temperature solution of 3-(1-{4-[3-(2,6-dichloro-phenyl)-5-isopropyl-3H-[1,2,3]triazol-4-ylmethoxy]-2-methyl-phenyl}-ethylsulfanyl)-benzoic acid methyl ester (53 mg, 0.0934 mmol) in dioxane (2 mL) is added a solution of lithium hydroxide (140 μL, 0.280 mmol, 2.0N in water). The reaction is heated to 50° C. for 2 h. The reaction mixture is concentrated and the residue is diluted with Et2O and water. The aqueous layer is adjusted to pH ˜4 and is extracted with a second portion of Et2O. The combined organic layers are washed with water, dried (MgSO4), filtered, and concentrated to yield the title compound (49 mg, 94%). LC-ES/MS m/e 556.3 (M+1), HPLC purity: 100%.

1. concentrationThe reaction mixture is concentrated
2. additionthe residue is diluted with Et2O and water
3. extractionis extracted with a second portion of Et2O
4. washThe combined organic layers are washed with water
5. dry with materialdried (MgSO4)
6. filtrationfiltered
7. concentrationconcentrated