Thionyl Chloride → HCID 86629254, compound

HRID 424832Notes

Reaction equation

S(Cl)([Cl:3])=O.[Br:5][C:6]1[CH:11]=[C:10]([O:12][CH2:13][C:14]2[N:15]([C:22]3[C:27]([Cl:28])=[CH:26][CH:25]=[CH:24][C:23]=3[Cl:29])[N:16]=[N:17][C:18]=2[CH:19]([CH3:21])[CH3:20])[CH:9]=[CH:8][C:7]=1[C:30]1[CH:35]=[CH:34][C:33]([C:36]([OH:38])=O)=[CH:32][CH:31]=1>>[Br:5][C:6]1[CH:11]=[C:10]([O:12][CH2:13][C:14]2[N:15]([C:22]3[C:23]([Cl:29])=[CH:24][CH:25]=[CH:26][C:27]=3[Cl:28])[N:16]=[N:17][C:18]=2[CH:19]([CH3:20])[CH3:21])[CH:9]=[CH:8][C:7]=1[C:30]1[CH:35]=[CH:34][C:33]([C:36]([Cl:3])=[O:38])=[CH:32][CH:31]=1

Participants

Reactant 2

HCID 24386Thionyl Chloride

HCID 66704215HCID 66704215, compound

Product 1

HCID 86629254HCID 86629254, compound

Procedure

To thionyl chloride (1.5 mL, 20 mmol) is added 2′-bromo-4′-[3-(2,6-dichloro-phenyl)-5-isopropyl-3H-[1,2,3]triazol-4-ylmethoxy]-biphenyl-4-carboxylic acid (0.074 g, 0.13 mmol). The reaction is stirred overnight at room temperature. The reaction mixture is concentrated under reduced pressure to give 2′-Bromo-4′-[3-(2,6-dichloro-phenyl)-5-isopropyl-3H-[1,2,3]triazol-4-ylmethoxy]-biphenyl-4-carbonyl chloride.

Workup

concentrationThe reaction mixture is concentrated under reduced pressure

Sources & evidence

ORD record: ord-691411d6e8794ec990442d44766fe2f0
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08106077B2

Reaction notes

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