Dichloromethane → HCID 57652735, compound

HRID 424833Notes

Reaction equation

[Br:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][C:10]2[N:11]([C:18]3[C:23]([Cl:24])=[CH:22][CH:21]=[CH:20][C:19]=3[Cl:25])[N:12]=[N:13][C:14]=2[CH:15]([CH3:17])[CH3:16])[CH:5]=[CH:4][C:3]=1[C:26]1[CH:31]=[CH:30][C:29]([C:32](Cl)=[O:33])=[CH:28][CH:27]=1.[CH:35]([NH2:39])([CH2:37][CH3:38])C.Cl[CH2:41]Cl>>[CH2:35]([NH:39][C:32]([C:29]1[CH:30]=[CH:31][C:26]([C:3]2[CH:4]=[CH:5][C:6]([O:8][CH2:9][C:10]3[N:11]([C:18]4[C:23]([Cl:24])=[CH:22][CH:21]=[CH:20][C:19]=4[Cl:25])[N:12]=[N:13][C:14]=3[CH:15]([CH3:16])[CH3:17])=[CH:7][C:2]=2[Br:1])=[CH:27][CH:28]=1)=[O:33])[CH:37]([CH3:41])[CH3:38]

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 24874Sec-Butylamine

HCID 86629254HCID 86629254, compound

Product 1

HCID 57652735HCID 57652735, compound

Procedure

To 2′-bromo-4′-[3-(2,6-dichloro-phenyl)-5-isopropyl-3H-[1,2,3]triazol-4-ylmethoxy]-biphenyl-4-carbonyl chloride (0.043 mmol) in dichloromethane (2 mL) is added s-butyl amine (0.05 mL, 0.5 mmol). The reaction is stirred at room temperature for 1 h and concentrated under reduced pressure. The residue is slurried in 1 N hydrochloric acid, and the solid is filtered to give the title compound (0.011 g). ES/MS m/e 617.0 (M+1).

Workup

concentrationconcentrated under reduced pressure
filtrationthe solid is filtered

Sources & evidence

ORD record: ord-3e9746e91f8f4841844cc9e64b5ef580
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08106077B2

Reaction notes

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