反应详情

温度

50 °C

A solution of 4-[({6-[5-isopropyl-3-(2-trifluoromethoxy-phenyl)-3H-[1,2,3]triazol-4-ylmethoxy]-2-methyl-pyridin-3-yl}-methyl-amino)-methyl]-2-methyl-benzoic acid methyl ester (147 mg, 0.251 mmol) in dioxane (2 mL) is treated with a solution of lithium hydroxide (378 mL, 0.756 mmol, 2.0N in water) and heated to 50° C. After 2 h, the reaction is concentrated and the residue is partitioned between Et2O and water. The aqueous layer is adjusted to pH ˜7 and is extracted with a second portion of Et2O. The combined organic layers are washed with water, dried (MgSO4), filtered, and concentrated to yield the title compound (138 mg, 97%). LC/MS (ES+): 570.0, 100%.

1. concentrationthe reaction is concentrated
2. customthe residue is partitioned between Et2O and water
3. extractionis extracted with a second portion of Et2O
4. washThe combined organic layers are washed with water
5. dry with materialdried (MgSO4)
6. filtrationfiltered
7. concentrationconcentrated