181371-35-7 → HCID 44139821, compound

HRID 424921Notes

Reaction equation

HRID 424921 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12](=[O:13])[CH:11]=[C:10]([CH3:14])[NH:9]2)=[CH:4][CH:3]=1.[F:15][C:16]([F:24])([F:23])[C:17](=[O:22])[C:18]([O:20][CH3:21])=[O:19]>C(Cl)(Cl)Cl>[CH3:21][O:20][C:18](=[O:19])[C:17]([OH:22])([C:16]([F:24])([F:23])[F:15])[C:11]1[C:12](=[O:13])[N:8]([C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)[NH:9][C:10]=1[CH3:14]

Participants

4

Reactant 2

HCID 341367181371-35-7HCID 2734931Methyl 3,3,3-trifluoro-2-oxopropanoate

Product 1

HCID 44139821HCID 44139821, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Conditions

Temperature
80 °C

Procedure

To a chloroform solution (5 ml) of 1-(4-fluorophenyl)-3-methyl-5-pyrazolone (96 mg, 0.5 mmol), methyl trifluoropyruvate (78 mg, 0.5 mmol) was added at room temperature and the mixture was stirred at 80° C. for 2 hours. After removing the solvent under reduced pressure, the title compound was obtained as a pale yellow solid (174 mg).

Workup

  1. customAfter removing the solvent under reduced pressure

Sources & evidence

ORD record
ord-2b822508d1324e449b384552c40b3c11
Source dataset
uspto-grants-2012_01
Patent number
US08106086B2

Reaction notes

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