Methyl 3,3,3-trifluoro-2-oxopropanoate → HCID 44139823, compound

HRID 424927Notes

Reaction equation

HRID 424927 reaction equation
[CH3:1][C:2]1[NH:3][N:4]([C:8]2[CH:13]=[CH:12][C:11]([CH3:14])=[CH:10][CH:9]=2)[C:5](=[O:7])[CH:6]=1.[F:15][C:16]([F:24])([F:23])[C:17](=[O:22])[C:18]([O:20][CH3:21])=[O:19]>C(Cl)(Cl)Cl>[CH3:21][O:20][C:18](=[O:19])[C:17]([OH:22])([C:16]([F:24])([F:23])[F:15])[C:6]1[C:5](=[O:7])[N:4]([C:8]2[CH:13]=[CH:12][C:11]([CH3:14])=[CH:10][CH:9]=2)[NH:3][C:2]=1[CH3:1]

Participants

4

Reactant 2

HCID 2734931Methyl 3,3,3-trifluoro-2-oxopropanoateHCID 27368983-Methyl-1-(4-methylphenyl)-1H-pyrazol-5-ol

Product 1

HCID 44139823HCID 44139823, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Conditions

Temperature
80 °C

Procedure

To a chloroform solution (5 ml) of 3-methyl-1-(4-methylphenyl)-5-pyrazolone (94 mg, 0.5 mmol), methyl trifluoropyruvate (78 mg, 0.5 mmol) was added at room temperature and the mixture was stirred at 80° C. for 2 hours. After removing the solvent under reduced pressure, the title compound was obtained as a pale yellow solid (172 mg).

Workup

  1. customAfter removing the solvent under reduced pressure

Sources & evidence

ORD record
ord-036b44fd43bd4eb6a33399ca900eb9ef
Source dataset
uspto-grants-2012_01
Patent number
US08106086B2

Reaction notes

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