Pyrrolidine → HCID 66703636, compound

HRID 425008Notes

Reaction equation

HRID 425008 reaction equation
[C:1]([O:5][C:6](=[O:19])[NH:7][C@@H:8]([C@@H:16]1[CH2:18][O:17]1)[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)([CH3:4])([CH3:3])[CH3:2].[NH:20]1[CH2:24][CH2:23][CH2:22][CH2:21]1>>[C:1]([O:5][C:6](=[O:19])[NH:7][C@H:8]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C@@H:16]([OH:17])[CH2:18][N:20]1[CH2:24][CH2:23][CH2:22][CH2:21]1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 11357515erythro-N-Boc-D-phenylalanine epoxide

Product 1

HCID 66703636HCID 66703636, compound

Procedure

Using general procedure 1 with [(1R)-1-{(2R)-oxiran-2-yl}-2-phenyl-ethyl]carbamic acid tert-butylester (0.133 g, 0.50 mmol) and pyrrolidine (0.210 mL, 2.50 mmol) gives the title compound.

Sources & evidence

ORD record
ord-c8c5f221fad4401a92b8d56fc761e540
Source dataset
uspto-grants-2012_01
Patent number
US08106090B2

Reaction notes

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