1,2,3,4-Tetrahydroisoquinoline → HCID 66703603, compound

HRID 425011Notes

Reaction equation

HRID 425011 reaction equation
[C:1]([O:5][C:6](=[O:21])[NH:7][C@@H:8]([C@@H:18]1[CH2:20][O:19]1)[CH2:9][C:10]1[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=1[F:17])([CH3:4])([CH3:3])[CH3:2].[CH2:22]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH2:25][CH2:24][NH:23]1>>[C:1]([O:5][C:6](=[O:21])[NH:7][C@H:8]([CH2:9][C:10]1[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=1[F:17])[C@@H:18]([OH:19])[CH2:20][N:23]1[CH2:24][CH2:25][C:26]2[C:31](=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH2:22]1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 70461,2,3,4-TetrahydroisoquinolineHCID 59786775HCID 59786775, compound

Product 1

HCID 66703603HCID 66703603, compound

Procedure

Using general procedure 1 and purification method D with [(1R)-1-{(2R)-oxiran-2-yl}-2-(2,5-difluoro-phenyl)-ethyl]carbamic acid tert-butylester (0.385 g, 1.3 mmol) and 1,2,3,4,-tetrahydro-isoquinoline (0.200 mL, 1.50 mmol) gives the title compound.

Sources & evidence

ORD record
ord-217cd3d8b0614f269228bc6ea10c2b13
Source dataset
uspto-grants-2012_01
Patent number
US08106090B2

Reaction notes

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