Azobisisobutyronitrile → HCID 59557730, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (5-bromo-2-chlorophenyl)(p-tolyl)methanone (intermediate AG) (16 g, 48.9 mmol) in CCl4 (80 mL), NBS (10.08 g, 57 mmol) and AIBN (0.848 g) was added. Then the mixture was heated to 90° C. After 3 h, CCl4 was removed under reduced pressure. The residue was dissolved in CH2Cl2 and the solution was washed 1× with HCl (1M) and 2× with brine prior to drying over Na2SO4. Solvent was removed under reduced pressure to obtain crude intermediate AH (20.75 g).

Provenance & Evidence