反应详情

温度

90 °C

To a solution of (5-bromo-2-chlorophenyl)(p-tolyl)methanone (intermediate AG) (16 g, 48.9 mmol) in CCl4 (80 mL), NBS (10.08 g, 57 mmol) and AIBN (0.848 g) was added. Then the mixture was heated to 90° C. After 3 h, CCl4 was removed under reduced pressure. The residue was dissolved in CH2Cl2 and the solution was washed 1× with HCl (1M) and 2× with brine prior to drying over Na2SO4. Solvent was removed under reduced pressure to obtain crude intermediate AH (20.75 g).

1. customCCl4 was removed under reduced pressure
2. dissolutionThe residue was dissolved in CH2Cl2
3. washthe solution was washed 1× with HCl (1M) and 2× with brine
4. dry with materialto drying over Na2SO4
5. customSolvent was removed under reduced pressure
6. customto obtain crude intermediate AH (20.75 g)