反应详情

In the fifth step of the process according to the invention, N-{(R)-2-hydroxy-3-[4-(3-oxomorpholin-4-yl)phenylamino}propyl]-5-chlorothiophene-2-carboxamide (X) is reacted with phosgene or a phosgene equivalent to give 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophene-carboxamide (I).