HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosgene → Phosgene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosgene | HCID 6371 | — |
| Reactant | 5-Chloro-N-((2R)-2-hydroxy-3-((4-(3-oxo-4-morpholinyl)phenyl)amino)propyl)-2-thiophenecarboxamide | HCID 10001574 | — |
| Product | Phosgene | HCID 6371 | — |
| Product | Rivaroxaban | HCID 9875401 | — |
Reaction Steps
In the fifth step of the process according to the invention, N-{(R)-2-hydroxy-3-[4-(3-oxomorpholin-4-yl)phenylamino}propyl]-5-chlorothiophene-2-carboxamide (X) is reacted with phosgene or a phosgene equivalent to give 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophene-carboxamide (I).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08106192B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-aff2855d8b68401fbadb405aa2b00583 |
| Source note | uspto-grants-2012_01 |