反应详情

(7S,8R)-8-Benzamido-1,4-dioxaspiro[4.5]decane-7-carboxylic acid (750 mg, 2.456 mmol) was dissolved in acetonitrile (10 mL) at 25° C. with stirring. 1N HCl (12.28 mL, 12.28 mmol) was then added thereto and the reaction stirred at 25° C. for about 16 hours. The reaction was concentrated to remove the acetonitrile. White solids precipitated and ethyl acetate and THF were added to dissolve the solids. The resulting mixture was rinsed (3×) with water. The organic layer was dried over sodium sulfate and concentrated to give (1S,2R)-2-benzamido-5-oxocyclohexanecarboxylic acid (430 mg, 1.646 mmol, 67.0% yield) as a white solid. MS (ESI+)=262.11 (M+H)+.

1. stirringthe reaction stirred at 25° C. for about 16 hours
2. concentrationThe reaction was concentrated
3. customto remove the acetonitrile
4. customWhite solids precipitated
5. additionethyl acetate and THF were added
6. dissolutionto dissolve the solids
7. washThe resulting mixture was rinsed (3×) with water
8. dry with materialThe organic layer was dried over sodium sulfate
9. concentrationconcentrated