Calcium Chloride → HCID 178488150, compound

HRID 425439Notes

Reaction equation

HRID 425439 reaction equation
[CH3:1][C:2]1[CH:3]=[N:4][C:5]([CH2:11][S+:12]([O-:24])[C:13]2[N-:14][C:15]3[CH:16]=[CH:17][C:18]([O:22][CH3:23])=[CH:19][C:20]=3[N:21]=2)=[C:6]([CH3:10])[C:7]=1[O:8][CH3:9].[Na+].[Cl-].[Ca+2:27].[Cl-]>O>[CH3:1][C:2]1[CH:3]=[N:4][C:5]([CH2:11][S+:12]([O-:24])[C:13]2[NH:14][C:15]3[CH:16]=[CH:17][C:18]([O:22][CH3:23])=[CH:19][C:20]=3[N:21]=2)=[C:6]([CH3:10])[C:7]=1[O:8][CH3:9].[Ca:27]

Participants

4

Reactant 2

HCID 5284359Calcium ChlorideHCID 178488037HCID 178488037, compound

Product 1

HCID 178488150HCID 178488150, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Conditions

Temperature
27.5 °C

Procedure

Esomeprazole sodium (20 gm, enantiomeric purity: 82%) is dissolved in water (200 ml) and then stirred for 10 minutes at 25-30° C. To the solution added a solution of calcium chloride (6 gm) in water (100 ml) for 15 minutes and stirred for 2 hours at 25-30° C. Filtered the solid, washed with water (40 ml) and then dried at 45-50° C. for 5-6 hours to give 18.2 gm of enantiomerically impure esomeprazole calcium salt (enantiomeric purity: 82%).

Workup

  1. stirringstirred for 2 hours at 25-30° C
  2. filtrationFiltered the solid
  3. washwashed with water (40 ml)
  4. customdried at 45-50° C. for 5-6 hours

Sources & evidence

ORD record
ord-a101fb795d8e48d4b52b358c69029ab9
Source dataset
uspto-grants-2012_01
Patent number
US08106210B2

Reaction notes

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