反应详情

温度

27.5 °C

Esomeprazole sodium (20 gm, enantiomeric purity: 82%) is dissolved in water (200 ml) and then stirred for 10 minutes at 25-30° C. To the solution added a solution of calcium chloride (6 gm) in water (100 ml) for 15 minutes and stirred for 2 hours at 25-30° C. Filtered the solid, washed with water (40 ml) and then dried at 45-50° C. for 5-6 hours to give 18.2 gm of enantiomerically impure esomeprazole calcium salt (enantiomeric purity: 82%).

1. stirringstirred for 2 hours at 25-30° C
2. filtrationFiltered the solid
3. washwashed with water (40 ml)
4. customdried at 45-50° C. for 5-6 hours