HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sesamol → 3-(4,5-difluoro-2-hydroxyphenyl)-3-hydroxy-1-pentyl-1,3-dihydro-2H-indol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sesamol | HCID 68289 | — |
| Reactant | 3,4-Difluorophenol | HCID 75927 | — |
| Reactant | 1-Pentyl-1H-indole-2,3-dione | HCID 1581092 | — |
| Reactant | 1-(2-cyclopropylethyl)-1H-indole-2,3-dione | HCID 65596570 | — |
| Product | 3-(4,5-difluoro-2-hydroxyphenyl)-3-hydroxy-1-pentyl-1,3-dihydro-2H-indol-2-one | HCID 12004303 | — |
Reaction Steps
Following the procedure as described in PREPARATION 2B, and making non-critical variations to replace 1-(2-cyclopropylethyl)-1H-indole-2,3-dione with 1-pentyl-1H-indole-2,3-dione, and 1,3-benzodioxol-5-ol with 3,4-difluorophenol, the title compound was obtained (31%): 1H NMR (300 MHz, CDCl3) δ 9.69-9.65 (br, 1H), 7.51-7.41 (m, 2H), 7.26-7.21 (m, 1H), 6.99-6.57 (m, 3H), 4.18-4.14 (br, 1H), 3.78-3.58 (m, 2H), 1.76-1.62 (m, 2H), 1.40-1.28 (m, 4H), 0.87 (t, 3H); MS (ES+) m/z 330 (M−17), 370 (M+23).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08106087B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-ffb70232c70f472492eec2949e89bba8 |
| Source note | uspto-grants-2012_01 |