Ammonia → 2-[4,6-Bis(4-fluorophenyl)-5-(4-pyridyl)pyrazolo[3,4-b]pyridin-1-yl]acetamide

HRID 42578Notes

Reaction equation

HRID 42578 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([C:14]3[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=3)=[C:12]([C:20]3[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=3)[N:11]=[C:10]3[N:27]([CH2:30][C:31](O)=[O:32])[N:28]=[CH:29][C:9]=23)=[CH:4][CH:3]=1.[NH3:34]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([C:14]3[CH:15]=[CH:16][N:17]=[CH:18][CH:19]=3)=[C:12]([C:20]3[CH:21]=[CH:22][C:23]([F:26])=[CH:24][CH:25]=3)[N:11]=[C:10]3[N:27]([CH2:30][C:31]([NH2:34])=[O:32])[N:28]=[CH:29][C:9]=23)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 670137062-[4,6-Bis(4-fluorophenyl)-5-(4-pyridyl)pyrazolo[3,4-b]pyridin-1-yl]acetic acid

Product 1

HCID 104110282-[4,6-Bis(4-fluorophenyl)-5-(4-pyridyl)pyrazolo[3,4-b]pyridin-1-yl]acetamideYield 36%

Procedure

Following a similar procedure to that described in example 48, but using 2-[4,6-bis(4-fluorophenyl)-5-(4-pyridyl)pyrazolo[3,4-b]pyridin-1-yl]acetic acid (obtained in example 45) instead of 2-[4,6-bis(4-fluorophenyl)-5-(4-pyridyl)pyrazolo[3,4-b]pyridin-2-yl]acetic acid, and aqueous NH3 instead of morpholine, the title compound was obtained (yield: 36%).

Sources & evidence

ORD record
ord-a73c4a90fc5c43a9a6efd5d73fe6ebe8
Source dataset
uspto-grants-2013_09
Patent number
US08536194B2

Reaction notes

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