Ammonia → 2-[4,6-Bis(4-fluorophenyl)-5-(4-pyridyl)pyrazolo[3,4-b]pyridin-1-yl]acetamide

Participants

Role	Name	HCID	Charge
Reactant	Ammonia	HCID 222	—
Reactant	2-[4,6-Bis(4-fluorophenyl)-5-(4-pyridyl)pyrazolo[3,4-b]pyridin-1-yl]acetic acid	HCID 67013706	—
Product	2-[4,6-Bis(4-fluorophenyl)-5-(4-pyridyl)pyrazolo[3,4-b]pyridin-1-yl]acetamide	HCID 10411028	36%

Reaction Steps

Following a similar procedure to that described in example 48, but using 2-[4,6-bis(4-fluorophenyl)-5-(4-pyridyl)pyrazolo[3,4-b]pyridin-1-yl]acetic acid (obtained in example 45) instead of 2-[4,6-bis(4-fluorophenyl)-5-(4-pyridyl)pyrazolo[3,4-b]pyridin-2-yl]acetic acid, and aqueous NH3 instead of morpholine, the title compound was obtained (yield: 36%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08536194B2
Source dataset	uspto-grants-2013_09
ORD ID	ord-a73c4a90fc5c43a9a6efd5d73fe6ebe8
Source note	uspto-grants-2013_09