Propylamine → 3-[4,6-Bis(4-fluorophenyl)-5-(4-pyridyl)pyrazolo[3,4-b]pyridin-1-yl]-N-propylpropionamide

HRID 42579Notes

Reaction equation

HRID 42579 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([C:14]3[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=3)=[C:12]([C:20]3[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=3)[N:11]=[C:10]3[N:27]([CH2:30][CH2:31][C:32]([OH:34])=O)[N:28]=[CH:29][C:9]=23)=[CH:4][CH:3]=1.[CH2:35]([NH2:38])[CH2:36][CH3:37]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([C:14]3[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=3)=[C:12]([C:20]3[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=3)[N:11]=[C:10]3[N:27]([CH2:30][CH2:31][C:32]([NH:38][CH2:35][CH2:36][CH3:37])=[O:34])[N:28]=[CH:29][C:9]=23)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 7852PropylamineHCID 684441763-[4,6-Bis(4-fluorophenyl)-5-(4-pyridyl)pyrazolo[3,4-b]pyridin-1-yl]propionic acid

Product 1

HCID 104585463-[4,6-Bis(4-fluorophenyl)-5-(4-pyridyl)pyrazolo[3,4-b]pyridin-1-yl]-N-propylpropionamideYield 76%

Procedure

Following a similar procedure to that described in example 48, but using 3-[4,6-bis(4-fluorophenyl)-5-(4-pyridyl)pyrazolo[3,4-b]pyridin-1-yl]propionic acid (obtained in example 47) instead of 2-[4,6-bis(4-fluorophenyl)-5-(4-pyridyl)pyrazolo[3,4-b]pyridin-2-yl]acetic acid, and propylamine instead of morpholine, the title compound was obtained (yield: 76%).

Sources & evidence

ORD record
ord-542f46996a9d408d87f1f691b4ce46e4
Source dataset
uspto-grants-2013_09
Patent number
US08536194B2

Reaction notes

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