6-Methylimidazo[2,1-B][1,3]thiazole-5-carboxylic acid → (1S,2S,5R)-2-{[6-Methyl-(imidazo[2,1-b]thiazole-5-carbonyl)-amino]-methyl}-7-methyl-3-aza-bicyclo[3.3.0]octane-3-carboxylic acid tert.-butyl ester

HRID 425803Notes

Reaction equation

HRID 425803 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:15][C@H:14]2[C@H:10]([CH2:11][CH:12]([CH3:16])[CH2:13]2)[C@H:9]1[CH2:17][NH2:18])=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:19][C:20]1[N:21]=[C:22]2[N:26]([C:27]=1[C:28](O)=[O:29])[CH:25]=[CH:24][S:23]2>>[C:1]([O:5][C:6]([N:8]1[CH2:15][C@H:14]2[C@H:10]([CH2:11][CH:12]([CH3:16])[CH2:13]2)[C@H:9]1[CH2:17][NH:18][C:28]([C:27]1[N:26]2[C:22]([S:23][CH:24]=[CH:25]2)=[N:21][C:20]=1[CH3:19])=[O:29])=[O:7])([CH3:3])([CH3:4])[CH3:2]

Participants

3

Reactant 2

HCID 3299796-Methylimidazo[2,1-B][1,3]thiazole-5-carboxylic acidHCID 59411604(1S,2S,5R)-2-aminomethyl-7-methyl-3-aza-bicyclo[3.3.0]-octane-3-carboxylic acid tert.-butyl ester

Product 1

HCID 59411634(1S,2S,5R)-2-{[6-Methyl-(imidazo[2,1-b]thiazole-5-carbonyl)-amino]-methyl}-7-methyl-3-aza-bicyclo[3.3.0]octane-3-carboxylic acid tert.-butyl ester

Procedure

prepared by reaction of (1S,2S,5R)-2-aminomethyl-7-methyl-3-aza-bicyclo[3.3.0]-octane-3-carboxylic acid tert.-butyl ester with commercially available 6-methyl-imidazo[2,1-b]thiazole-5-carboxylic acid.

Sources & evidence

ORD record
ord-f7b0212d584b469c98d70d25bb4cd4d4
Source dataset
uspto-grants-2012_01
Patent number
US08106215B2

Reaction notes

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