反应详情

To a mixture of ethyl 5-{6-amino-5-[(2,6-dichlorobenzyl)oxy]pyridin-3-yl}-1H-indole-2-carboxylate (2.5 g, 5.5 mmol) in methanol:water (60 mL:20 mL), lithium hydroxide (0.65 g, 27.1 mmol) was added. The reaction was heated to reflux for overnight. Most of the solvent was evaporated and the mixture was acidified, and stirred for 10 min. The precipitate was filtered out and washed with water to yield 5-{6-amino-5-[(2,6-dichlorobenzyl)oxy]pyridin-3-yl}-1H-indole-2-carboxylic acid as tan solid.

1. temperatureThe reaction was heated
2. temperatureto reflux for overnight
3. customMost of the solvent was evaporated
4. filtrationThe precipitate was filtered out
5. washwashed with water