4-(1,1-Dioxido-2-isothiazolidinyl)phenylboronic Acid Pinacol Ester → 3-(2-Chloro-3,6-difluoro-benzyloxy)-5-[4-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-phenyl]-pyridin-2-ylamine

HRID 425947Notes

Reaction equation

HRID 425947 reaction equation
Br[C:2]1[CH:3]=[C:4]([O:9][CH2:10][C:11]2[C:16]([F:17])=[CH:15][CH:14]=[C:13]([F:18])[C:12]=2[Cl:19])[C:5]([NH2:8])=[N:6][CH:7]=1.CC1(C)C(C)(C)OB([C:28]2[CH:33]=[CH:32][C:31]([N:34]3[CH2:38][CH2:37][CH2:36][S:35]3(=[O:40])=[O:39])=[CH:30][CH:29]=2)O1>>[Cl:19][C:12]1[C:13]([F:18])=[CH:14][CH:15]=[C:16]([F:17])[C:11]=1[CH2:10][O:9][C:4]1[C:5]([NH2:8])=[N:6][CH:7]=[C:2]([C:28]2[CH:29]=[CH:30][C:31]([N:34]3[CH2:38][CH2:37][CH2:36][S:35]3(=[O:40])=[O:39])=[CH:32][CH:33]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 211113814-(1,1-Dioxido-2-isothiazolidinyl)phenylboronic Acid Pinacol EsterHCID 211114915-Bromo-3-((2-chloro-3,6-difluorobenzyl)oxy)pyridin-2-amine

Product 1

HCID 588864123-(2-Chloro-3,6-difluoro-benzyloxy)-5-[4-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-phenyl]-pyridin-2-ylamine

Procedure

3-(2-Chloro-3,6-difluoro-benzyloxy)-5-[4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-phenyl]-pyridin-2-ylamine was prepared following procedure 3 from 5-bromo-3-(2-chloro-3,6-difluoro-benzyloxy)-pyridin-2-ylamine and 2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-phenyl]isothiazolidine 1,1-dioxide.

Sources & evidence

ORD record
ord-f75598a5368b48a7872a772d7b003d0b
Source dataset
uspto-grants-2012_01
Patent number
US08106197B2

Reaction notes

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