HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(1,1-Dioxido-2-isothiazolidinyl)phenylboronic Acid Pinacol Ester → 3-(2-Chloro-3,6-difluoro-benzyloxy)-5-[4-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-phenyl]-pyridin-2-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(1,1-Dioxido-2-isothiazolidinyl)phenylboronic Acid Pinacol Ester | HCID 21111381 | — |
| Reactant | 5-Bromo-3-((2-chloro-3,6-difluorobenzyl)oxy)pyridin-2-amine | HCID 21111491 | — |
| Product | 3-(2-Chloro-3,6-difluoro-benzyloxy)-5-[4-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-phenyl]-pyridin-2-ylamine | HCID 58886412 | — |
Reaction Steps
3-(2-Chloro-3,6-difluoro-benzyloxy)-5-[4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-phenyl]-pyridin-2-ylamine was prepared following procedure 3 from 5-bromo-3-(2-chloro-3,6-difluoro-benzyloxy)-pyridin-2-ylamine and 2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-phenyl]isothiazolidine 1,1-dioxide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08106197B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-f75598a5368b48a7872a772d7b003d0b |
| Source note | uspto-grants-2012_01 |