HRID425956

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C(O)C(O)(C(=O)c1ccccc1)C(O)(C(=O)O)C(=O)c1ccccc1

HCID12362975

未命名化合物

HCID14608417

未命名化合物

PRODUCTS

生成物

结构：NC(=O)[C@H](O)[C@@H](N)c1ccccc1.O=C(O)C(O)(C(=O)c1ccccc1)C(O)(C(=O)O)C(=O)c1ccccc1

HCID131729427

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

Racemic threo 3-phenylisoserine amide (IX) (120.0 g, 0.67 mole) and (−)-dibenzoyltartaric acid (240.1 g, 0.67 mole) were suspended in ethanol (1080.0 g). The suspension was refluxed for 2 hours, then cooled to room temperature and stirred for further 60 minutes. The product was filtered off, washed with ethanol (400.0 g) and vacuum dried at 50° C. Yield: 180.6 g (0.34 mole, 50%).

WORKUP

后处理

temperatureThe suspension was refluxed for 2 hours
filtrationThe product was filtered off
washwashed with ethanol (400.0 g) and vacuum
customdried at 50° C

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-40201be001ab4f0bbdd3ae40ba67ce70
来源数据集: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08106231B2
来源说明: uspto-grants-2012_01

反应 SMILES

[C:1]1([CH:7]([CH:9]([C:11]([NH2:13])=[O:12])[OH:10])[NH2:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:14]([C:22]([C:37]([OH:39])=[O:38])([OH:36])[C:23]([C:28](=[O:35])[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)([OH:27])[C:24]([OH:26])=[O:25])(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C(O)C>[C:28]([C:23]([C:24]([OH:26])=[O:25])([OH:27])[C:22]([C:14](=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)([OH:36])[C:37]([OH:39])=[O:38])(=[O:35])[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1.[C:1]1([C@@H:7]([C@H:9]([C:11]([NH2:13])=[O:12])[OH:10])[NH2:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1