反应详情

温度

42 °C

(2R,3S)-3-Phenylisoserine amide dibenzoyl-tartaric acid salt (X) (180.6 g, 0.34 mole) was suspended in ethanol (535.0 g) and the mixture was heated to 42° C. 46.2 g of concentrated hydrochlorid acid (32%) was then slowly added to the suspension keeping the temperature at about 45° C. After completion of the addition the mixture was cooled down to 0° C. over a period of 1 hour and stirred for 1 further hour. The product was filtered off, washed with ethanol (100.0 g) and vacuum dried at 80° C. Yield: 60.5 g (0.28 mole, 82.0%).

1. customat about 45° C
2. additionAfter completion of the addition the mixture
3. temperaturewas cooled down to 0° C. over a period of 1 hour
4. filtrationThe product was filtered off
5. washwashed with ethanol (100.0 g) and vacuum
6. customdried at 80° C