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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 425961Generated: November 4, 2026

1,4-Dibromobutane → 4-chloro-2-{[(1S*,2S*)-2-pyrrolidin-1-ylcyclohexyl]amino}benzonitrile

https://huagongshe.com/reaction/425961

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4-DibromobutaneHCID 8056—
ReactantSodium CarbonateHCID 10340—
Reactant2-{[(1S,2S)-2-aminocyclohexyl]amino}-4-chlorobenzonitrileHCID 66703792—
SolventAcetonitrileHCID 6342—
Product4-chloro-2-{[(1S*,2S*)-2-pyrrolidin-1-ylcyclohexyl]amino}benzonitrileHCID 66703634—

Reaction Steps

Sodium carbonate and 1,4-dibromobutane were added to an acetonitrile solution of 2-{[(1S*,2S*)-2-aminocyclohexyl]amino}-4-chlorobenzonitrile, followed by heating under reflux for 2 days. By post-treating the reaction liquid, 4-chloro-2-{[(1S*,2S*)-2-pyrrolidin-1-ylcyclohexyl]amino}benzonitrile was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08106190B2
Source datasetuspto-grants-2012_01
ORD IDord-ab198210ab394fe1b73f65e35dc883b8
Source noteuspto-grants-2012_01