Sodium Hydroxide → 5-Chloro-2-(cyclohexylamino)benzoic acid

HRID 425967Notes

Reaction equation

HRID 425967 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:12][CH:13]2[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]2)=[C:6]([CH:11]=1)[C:7]([O:9]C)=[O:8].[OH-].[Na+]>C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:12][CH:13]2[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]2)=[C:6]([CH:11]=1)[C:7]([OH:9])=[O:8]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 12329834Methyl 5-chloro-2-(cyclohexylamino)benzoate

Product 1

HCID 123298335-Chloro-2-(cyclohexylamino)benzoic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
70 °C

Procedure

Methyl 5-chloro-2-(cyclohexylamino)benzoate was dissolved in ethanol, a 1 M sodium hydroxide aqueous solution was added, followed by stirring at 70° C. By post-treating the reaction liquid, 5-chloro-2-(cyclohexylamino)benzoic acid was obtained.

Workup

  1. additionBy post-treating
  2. customthe reaction liquid

Sources & evidence

ORD record
ord-d841805acea54491801abcd36fb460c1
Source dataset
uspto-grants-2012_01
Patent number
US08106190B2

Reaction notes

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