HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 425970Generated: October 25, 2026
Methyl iodide → 2-[(1,2,2,6,6-Pentamethylpiperidin-4-yl)amino]-4-(trifluoromethyl)benzonitrile
https://huagongshe.com/reaction/425970
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Amino-2,2,6,6-tetramethylpiperidine | HCID 37524 | — |
| Reactant | 2-Fluoro-4-(trifluoromethyl)benzonitrile | HCID 518973 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-[(1,2,2,6,6-Pentamethylpiperidin-4-yl)amino]-4-(trifluoromethyl)benzonitrile | HCID 66703819 | — |
Reaction Steps
Potassium carbonate and 2,2,6,6-tetramethylpiperidine-4-amine were added to a DMF solution of 2-fluoro-4-(trifluoromethyl)benzonitrile. After stirring at 60° C. for 12 hours, methyl iodide and potassium carbonate were added thereto, followed by stirring at room temperature for 1 day. By post-treating the reaction liquid, 2-[(1,2,2,6,6-pentamethylpiperidin-4-yl)amino]-4-(trifluoromethyl)benzonitrile was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08106190B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-a89b48ad1ae34fddbdd780522d7c2ed2 |
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| Source note | uspto-grants-2012_01 |
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