反应详情

温度

60 °C

Potassium carbonate and 2,2,6,6-tetramethylpiperidine-4-amine were added to a DMF solution of 2-fluoro-4-(trifluoromethyl)benzonitrile. After stirring at 60° C. for 12 hours, methyl iodide and potassium carbonate were added thereto, followed by stirring at room temperature for 1 day. By post-treating the reaction liquid, 2-[(1,2,2,6,6-pentamethylpiperidin-4-yl)amino]-4-(trifluoromethyl)benzonitrile was obtained.

1. stirringby stirring at room temperature for 1 day
2. additionBy post-treating
3. customthe reaction liquid