Hydrochloric Acid → HCID 66703661, compound

Participants

Reaction Steps

tert-Butoxy potassium was added to a mixture of 2-fluoro-4-(trifluoromethyl)benzonitrile, 3-pyridine amine and THF, followed by stirring at room temperature for 7 hours. After neutralizing the reaction liquid by adding 1 M hydrochloric acid thereto and subsequent extraction with chloroform, the solvent was evaporated under a reduced pressure. The residue was purified by column chromatography to obtain 2-(pyridine-3-ylamino)-4-(trifluoromethyl)benzonitrile.

Provenance & Evidence