Hydrochloric Acid → HCID 66703661, compound

HRID 425973Notes

Reaction equation

HRID 425973 reaction equation
C(O[K])(C)(C)C.F[C:8]1[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[CH:12][C:9]=1[C:10]#[N:11].[N:20]1[CH:25]=[CH:24][CH:23]=[C:22]([NH2:26])[CH:21]=1.Cl>C1COCC1>[N:20]1[CH:25]=[CH:24][CH:23]=[C:22]([NH:26][C:8]2[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[CH:12][C:9]=2[C:10]#[N:11])[CH:21]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 100093-AminopyridineHCID 5189732-Fluoro-4-(trifluoromethyl)benzonitrileHCID 178418922HCID 178418922, compound

Product 1

HCID 66703661HCID 66703661, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

tert-Butoxy potassium was added to a mixture of 2-fluoro-4-(trifluoromethyl)benzonitrile, 3-pyridine amine and THF, followed by stirring at room temperature for 7 hours. After neutralizing the reaction liquid by adding 1 M hydrochloric acid thereto and subsequent extraction with chloroform, the solvent was evaporated under a reduced pressure. The residue was purified by column chromatography to obtain 2-(pyridine-3-ylamino)-4-(trifluoromethyl)benzonitrile.

Workup

  1. customthe reaction liquid
  2. extractionsubsequent extraction with chloroform
  3. customthe solvent was evaporated under a reduced pressure
  4. customThe residue was purified by column chromatography

Sources & evidence

ORD record
ord-c1f132a266fb495e8eb31e812832b708
Source dataset
uspto-grants-2012_01
Patent number
US08106190B2

Reaction notes

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