HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → HCID 66703739, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | HCID 66703881 | HCID 66703881 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 66703739 | HCID 66703739 | — |
Reaction Steps
In DMF and in the presence of sodium hydride, methyl 2-({(1S,2S)-2-[(tert-butoxycarbonyl)amino]cyclohexyl}amino)-4-(trifluoromethyl)benzoate was allowed to react with methyl iodide at 70° C. for 1 hour. By post-treating the reaction liquid, methyl 2-({(1S,2S)-2-[(tert-butoxycarbonyl)(methyl)amino]cyclohexyl}amino)-4-(trifluoromethyl)benzoate was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08106190B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-8ade99ba53b84c9baff8c6172e002c73 |
| Source note | uspto-grants-2012_01 |