Methyl iodide → HCID 66703739, compound

HRID 425976Notes

Reaction equation

HRID 425976 reaction equation
[H-].[Na+].[C:3]([O:7][C:8]([NH:10][C@H:11]1[CH2:16][CH2:15][CH2:14][CH2:13][C@@H:12]1[NH:17][C:18]1[CH:27]=[C:26]([C:28]([F:31])([F:30])[F:29])[CH:25]=[CH:24][C:19]=1[C:20]([O:22][CH3:23])=[O:21])=[O:9])([CH3:6])([CH3:5])[CH3:4].[CH3:32]I>CN(C=O)C>[C:3]([O:7][C:8]([N:10]([CH3:32])[C@H:11]1[CH2:16][CH2:15][CH2:14][CH2:13][C@@H:12]1[NH:17][C:18]1[CH:27]=[C:26]([C:28]([F:29])([F:30])[F:31])[CH:25]=[CH:24][C:19]=1[C:20]([O:22][CH3:23])=[O:21])=[O:9])([CH3:6])([CH3:4])[CH3:5]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 66703881HCID 66703881, compound

Product 1

HCID 66703739HCID 66703739, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In DMF and in the presence of sodium hydride, methyl 2-({(1S,2S)-2-[(tert-butoxycarbonyl)amino]cyclohexyl}amino)-4-(trifluoromethyl)benzoate was allowed to react with methyl iodide at 70° C. for 1 hour. By post-treating the reaction liquid, methyl 2-({(1S,2S)-2-[(tert-butoxycarbonyl)(methyl)amino]cyclohexyl}amino)-4-(trifluoromethyl)benzoate was obtained.

Workup

  1. additionBy post-treating
  2. customthe reaction liquid

Sources & evidence

ORD record
ord-8ade99ba53b84c9baff8c6172e002c73
Source dataset
uspto-grants-2012_01
Patent number
US08106190B2

Reaction notes

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