huagongshe.com
HRID425978

反应详情

EQUATION

反应方程式

HRID 425978 的结构方程式

REACTANTS

反应物

3
结构：F.FB(F)F
HCID9855450

未命名化合物

结构：O=N[O-].[Na+]
HCID23668193

Sodium Nitrite

NNaO2

结构：CCOC(=O)c1ccc(N)cc1N[C@H]1CCCC[C@@H]1N1CCCC1
HCID66703696

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)c1ccc(F)cc1N[C@H]1CCCC[C@@H]1N1CCCC1
HCID66703633

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

Ethyl 4-amino-2-{[(1S,2S)-2-pyrrolidin-1-ylcyclohexyl]amino}benzoate was allowed to react with sodium nitrite (NaNO2) and trifluoroborane-hydrogen fluoride complex (BF3.HF) in water at 10° C. for 10 minutes. By post-treating the reaction liquid, ethyl 4-fluoro-2-{[(1S,2S)-2-pyrrolidin-1-ylcyclohexyl]amino}benzoate was obtained.

WORKUP

后处理

  1. additionBy post-treating
  2. customthe reaction liquid